abstract：:The effect of N-benzyl-D-glucamine dithiocarbamate (BGD) on the renal toxicity induced by acute exposure to cadmium-metallothionein (Cd-MT) in rats was studied. Rats were injected intraperitoneally with BGD (400 mumol/kg) 6, 12, or 24 h after intraperitoneal injection of Cd-MT (1.78 mumol Cd as Cd-MT/kg) and thereafte...

journal_title：Archives of toxicology

authors： Kojima S,Ono H,Furukawa A,Kiyozumi M

更新日期：1990-01-01 00:00:00

abstract：:The activity of 18 vitamin D analogs on soft tissue calcification and growth impairment in neonatal rats and their effect on bone calcium mobilization, intestinal calcium absorption and binding to intestinal 1,25-dihydroxyvitamin D3 receptors in adult rats were compared. Depending on the chemical modification of the v...

journal_title：Archives of toxicology

authors： Kistler A,Galli B,Horst R,Truitt GA,Uskoković MR

更新日期：1989-01-01 00:00:00

abstract：:Initially, mice were pretreated with atropine (17.4 mg/kg; IP) and the oxime reactivator HI-6 (50 mg/kg; IP) 5 min prior to an injection of soman (287 micrograms/kg, SC); approximately 2.1 x LD50 dose). More than 95% of the mice survived this dose of soman with atropine and HI-6 pretreatment. In these survivors of som...

journal_title：Archives of toxicology

authors： Clement JG

更新日期：1989-01-01 00:00:00

abstract：:The genotoxicity of the sensory irritant 2-chlorobenzylidene malonitrile (CS) to V79 Chinese hamster cells was investigated using the induction of gene mutations, micronuclei and DNA repair synthesis as biological endpoints. CS efficiently induced micronuclei and mutants resistant to 6-thioguanine in these cells, but ...

journal_title：Archives of toxicology

authors： Ziegler-Skylakakis K,Summer KH,Andrae U

更新日期：1989-01-01 00:00:00

abstract：:Organophosphate-induced delayed polyneuropathy (OPIDP) is initiated by inhibition/aging of more than 70-75% of neuropathy target esterase (NTE). Di-n-butyl-2,2-dichlorovinyl phosphate (DBDCVP) (1 mg/kg s.c.) inhibited 96%, 86% and 83% of NTE in brain, spinal cord and peripheral nerve, respectively, and induced a typic...

journal_title：Archives of toxicology

authors： Moretto A,Lotti M,Spencer PS

更新日期：1989-01-01 00:00:00

abstract：:Dorsal root ganglia from control and methylmercury (MeHg)-treated rats were incubated in vitro with 35S-methionine ant the proteins synthesized were analyzed by two-dimensional electrophoresis. The double labelling method, in which proteins of control dorsal root ganglia labelled in vitro with 3H-leucine were added to...

journal_title：Archives of toxicology

authors： Kasama H,Itoh K,Omata S,Sugano H

更新日期：1989-01-01 00:00:00

abstract：:The mechanical properties of the bones of young, adult and old rats administered various concentrations of cadmium were measured to prove the direct effect of cadmium on the bones of young rats. The young rats were divided into three subgroups, which were administered 0 (control), 5 and 10 ppm cadmium, respectively. T...

journal_title：Archives of toxicology

authors： Ogoshi K,Moriyama T,Nanzai Y

更新日期：1989-01-01 00:00:00

abstract：:Previous histomorphometric studies led us to hypothesize that suppression of hepatocellular regeneration and the repair of the hepatolobular architecture was involved besides bioactivation phenomenon in the progressive and irreversible phase of toxicity resulting from CD + CCl4 interaction. We have recently observed s...

journal_title：Archives of toxicology

authors： Kodavanti PR,Joshi UM,Young RA,Bell AN,Mehendale HM

更新日期：1989-01-01 00:00:00

abstract：:Recent work concerned with the mechanism underlying the development of organophosphorous compound-induced delayed neurotoxicity (OPIDN) is reviewed. Topics covered include the prophylaxis of OPIDN by phenylmethylsulfonyl fluoride and other agents, neurotoxic esterase (NTE) as measured using either labelled di-isopropy...

journal_title：Archives of toxicology

authors： Carrington CD

更新日期：1989-01-01 00:00:00

abstract：:A study was conducted to determine the levels of cis-diamminedichloroplatinum (II) (cisplatin) in plasma proteins and hemoglobin of cancer patients after cisplatin chemotherapy. Thirty-seven cancer patients with different type of cancers (lung, esophageal, urinary tract, and testicular cancer, melanoma, osteosarcoma e...

journal_title：Archives of toxicology

authors： Mustonen R,Hietanen P,Leppälä S,Takala M,Hemminki K

更新日期：1989-01-01 00:00:00

abstract：:The effects of cadmium exposure during pregnancy (by means of daily subcutaneous injections of 4.4 mumol/kg to the mother) on the neonates were investigated. No effect was observed on fetal or neonatal body weights, nor on neonatal liver weights. These parameters were examined up to 5 weeks after birth. The weight of ...

journal_title：Archives of toxicology

authors： Hazelhoff Roelfzema W,Roelofsen AM,Leene W,Peereboom-Stegeman HJ

更新日期：1989-01-01 00:00:00

abstract：:Orally administered meso-2,3-dimercaptosuccinic acid (DMSA) is an effective antagonist for acute oral cadmium chloride (1 mmol/kg) intoxication in mice when administered up to 8 h after cadmium ingestion. Administration of sodium N-benzyl-N-dithiocarboxy-D-glucamine (NaB) i.p. along with DMSA p.o. resulted in kidney a...

journal_title：Archives of toxicology

authors： Jones MM,Basinger MA,Topping RJ,Gale GR,Jones SG,Holscher MA

更新日期：1988-08-01 00:00:00

abstract：:The pregnancy outcomes of 109 women who were intoxicated during pregnancy due to excessive amounts of drugs and other agents were studied. Seventy per cent of the women attempted suicide, and the intoxication in 78% of all cases was caused by drugs. The stillbirth rate (4%) was higher than that in previous and subsequ...

journal_title：Archives of toxicology

authors： Czeizel A,Szentesi I,Szekeres I,Molnár G,Glauber A,Bucski P

更新日期：1988-08-01 00:00:00

abstract：:Degradation of neurofilament (NF) proteins by Ca2+-activated neutral protease (CANP) was studied in the nervous system of rats treated with neurotoxic or non-neurotoxic compounds. In the tibial nerve, the degradation of NF 68K was depressed by five neurotoxic compounds: acrylamide, N-hydroxymetylacrylamide, N-isopropy...

journal_title：Archives of toxicology

authors： Tanii H,Hayashi M,Hashimoto K

更新日期：1988-08-01 00:00:00

abstract：:A histochemical technique for detection of the in vivo induced cellular aldehydes based on the direct Schiff's reaction is reported in this paper. CCl4-intoxicated rat liver was used as an experimental model. Fresh and non-pretreated rat liver cryostat sections fixed in 10% formol calcium solution and washed in distil...

journal_title：Archives of toxicology

authors： Taper HS,Somer MP,Lans M,de Gerlache J,Roberfroid M

更新日期：1988-04-01 00:00:00

abstract：:N-methylformamide (NMF) produced dose-dependent zone 3 haemorrhagic necrosis in mice; the threshold dose was 100-200 mg/kg. In rats a dose of 1000 mg/kg caused hepatic damage in some animals and slight elevations of plasma transaminases. A species difference in susceptibility to NMF-induced hepatotoxicity is clearly i...

journal_title：Archives of toxicology

authors： Tulip K,Timbrell JA

更新日期：1988-01-01 00:00:00

abstract：:The urinary and faecal excretion of chrysene and its phenolic metabolites after oral, intraperitoneal, intratracheal, and intrapulmonary administration to rats have been studied by means of gas chromatography/mass spectrometry. The metabolite profile was found to depend on the mode of excretion and on the route of adm...

journal_title：Archives of toxicology

authors： Grimmer G,Brune H,Dettbarn G,Heinrich U,Jacob J,Mohtashamipur E,Norpoth K,Pott F,Wenzel-Hartung R

更新日期：1988-01-01 00:00:00

abstract：:Pregnant C3H mice were exposed to a teratogenic dose of cyclophosphamide (CP, 20 mg/kg body weight) on the 10th day after copulation. Embryos or fetuses were examined 2-9 days later for gross abnormalities, weighed, and assayed for cephalic acetylcholinesterase (EC 3.1.1.7, AChE) activity, and haemoglobin content. In ...

journal_title：Archives of toxicology

authors： Pillans PI,Stephenson BA,Folb PI

更新日期：1988-01-01 00:00:00

abstract：:The tissue distribution, metabolism and excretion of 14C-2,2',4,4',5-pentachlorodiphenyl ether (PCDE) were studied in the rat. Radioactivity was distributed in all tissues examined, with the highest concentrations being found in the fat followed by the skin, liver, kidney and muscle. Most of the radioactivity found in...

journal_title：Archives of toxicology

authors： Komsta E,Chu I,Villeneuve DC,Benoit FM,Murdoch D

更新日期：1988-01-01 00:00:00

abstract：:DNA binding in vivo: [6,7-3H]beta-trenbolone (beta-TBOH) was administered p.o. and i.p. to rats. After 8 or 16 h, DNA was isolated from the livers and purified to constant specific radioactivity. Enzymatic digestion to deoxyribonucleotides and separation by HPLC revealed about 90% of the DNA radioactivity eluting in t...

journal_title：Archives of toxicology

authors： Lutz WK,Deuber R,Caviezel M,Sagelsdorff P,Friederich U,Schlatter C

更新日期：1988-01-01 00:00:00

abstract：:Cadmium-induced metallothionein (MT) synthesis was investigated in male rats of three ages, 3, 12 and 24 months. Physiological levels of MT in kidney, liver and lung measured simultaneously in untreated animals were found to be within the same range in all three age groups. Following 3-day treatment with CdCl2 equival...

journal_title：Archives of toxicology

authors： Wormser U,Nir I

更新日期：1988-01-01 00:00:00

abstract：:Purified phenobarbital-induced rat liver cytochrome P-450 was incorporated in a reconstituted system containing NADPH-cytochrome P-450 reductase, dilauroyl phosphatidyl choline and sodium cholate. This system was added to organ cultures of limb buds from mouse embryos on day 11 of gestation. Cyclophosphamide (100 micr...

journal_title：Archives of toxicology

authors： Kastner M,Blankenburg G,Schulz T,Schack G,Neubert D

更新日期：1988-01-01 00:00:00

abstract：:The ethylene oxide adduct formed on the N-terminal valine in haemoglobin was investigated as a biological monitor of tobacco smoke intake. The modified method developed for the determination of the hydroxyethylvaline adduct (HOEtVal) involved reaction of globin with pentafluorophenyl isothiocyanate, extraction of the ...

journal_title：Archives of toxicology

authors： Bailey E,Brooks AG,Dollery CT,Farmer PB,Passingham BJ,Sleightholm MA,Yates DW

更新日期：1988-01-01 00:00:00

abstract：:The effects of intravenously (i.v.) administered or inhaled amyl nitrite (AN) were followed under chloralose anaesthesia in intact and cyanide-poisoned, spontaneously breathing beagles. The i.v. doses of AN were 0.03 and 0.15 mmol/kg and the i.v. dose of KCN was 0.06 mmol/kg. AN was inhaled in a closed system at 0.15 ...

journal_title：Archives of toxicology

authors： Klimmek R,Krettek C

更新日期：1988-01-01 00:00:00

abstract：:The metabolic fate of 2-ethylhexyl diphenyl phosphate (EHDPP) was studied in male rats. Orally administered 14C-EHDPP was rapidly absorbed and about 80% of the radioactivity was excreted in the urine and feces in the first 24 h. By 7 days, 48% and 52% of the radioactivity was recovered in urine and feces, respectively...

journal_title：Archives of toxicology

authors： Nishimaki-Mogami T,Minegishi K,Tanaka A,Sato M

更新日期：1988-01-01 00:00:00

abstract：:Certain populations of the mosquitofish (Gambusia affinis) are highly resistant to cyclodiene and cyclodiene-type insecticides that competitively interact with the picrotoxinin binding site of the gamma-aminobutyric acid (GABA) receptor-ionophore complex in the central nervous system. Resistance involves a reduction i...

journal_title：Archives of toxicology

authors： Bonner JC,Yarbrough JD

更新日期：1988-01-01 00:00:00

abstract：:The investigation was aimed at providing insight into the side chain metabolism of furazolidone in mice. The agents used in the experiments were furazolidone, 3-amino-2-oxazolidinone, oxazolidinone, nitrofurantoin, 3-aminohydantoin and hydantoin, administered intraperitoneally at five equimolar doses ranging from 0.17...

journal_title：Archives of toxicology

authors： Hunder G,Schmid A,Mayring L

更新日期：1987-12-01 00:00:00

abstract：:Prudhoe Bay crude oil (PBCO) and its aliphatic, aromatic and heterocyclic fractions were tested on the developing chick embryo for (i) embryotoxicity (ii) their ability to induce hepatic and renal cytochrome P450 levels as well as hepatic, renal and pulmonary aryl hydrocarbon hydroxylase activities. On the basis of it...

journal_title：Archives of toxicology

authors： Walters P,Khan S,O'Brien PJ,Payne JF,Rahimtula AD

更新日期：1987-08-01 00:00:00

abstract：:The aim of our study was to determine the period of maximum sensitivity for the induction of characteristic malformations with thalidomide (TH) in Himalayan rabbits. TH was administered orally in different doses (50, 100, 150 and 200 mg/kg) four times at 24-h intervals starting at 192 h of gestation. The malformations...

journal_title：Archives of toxicology

authors： Sterz H,Nothdurft H,Lexa P,Ockenfels H

更新日期：1987-07-01 00:00:00

abstract：:Cadmium, copper and zinc have been determined in kidney cortex, kidney medulla and liver from 51 cadmium-polluted and 122 nonpolluted autopsied subjects. Liver cadmium and zinc were significantly higher in the cadmium-polluted subjects than in the nonpolluted subjects. Kidney cadmium, copper and zinc were lower in the...

journal_title：Archives of toxicology

authors： Honda R,Nogawa K

更新日期：1987-04-01 00:00:00

abstract：:The effect of duration of employment at a North American cadmium smelter on urinary metallothionein (MT), total protein, beta 2-microglobulin (beta 2-MG), glucose, cadmium, copper and zinc of 53 men was studied. The levels of all urinary parameters increased with the duration of employment. Smoking history did not aff...

journal_title：Archives of toxicology

authors： Shaikh ZA,Tohyama C,Nolan CV

更新日期：1987-02-01 00:00:00

abstract：:Assay conditions in determining total cytochrome P-450 in four laboratories were compared. Although the determination was derived from the original Omura and Sato method in each laboratory, the four standard protocols differed slightly, resulting in considerable differences in the results. Since the cytochrome P-450 c...

journal_title：Archives of toxicology

authors： Rutten AA,Falke HE,Catsburg JF,Topp R,Blaauboer BJ,van Holsteijn I,Doorn L,van Leeuwen FX

更新日期：1987-01-01 00:00:00

abstract：:Changes in the urinary excretion of hippuric acid (HIA) and phenaceturic acid (PUA) as well as their metabolic precursors, i.e. benzoic (BA) and phenylacetic acid (PAA), in rats housed in glass metabolic cages for 4 days were monitored using gas-liquid chromatography. The amount of HIA excreted was 128 +/- 63 mumol/kg...

journal_title：Archives of toxicology

authors： Linhart I,Smejkal J

更新日期：1987-01-01 00:00:00

abstract：:The estimation of risk and evaluation of risk/benefit are traditionally and by necessity oriented at the current state of science and technology to ensure contemporary rights of safety. This demands a careful development in the methodology of hazard identification and risk assessment and its continuous updating and in...

journal_title：Archives of toxicology

authors： Hildebrandt AG

更新日期：1987-01-01 00:00:00

abstract：:Many carcinogens and mutagens are electrophilic in nature and will react with nucleophilic sites in protein and nucleic acid. Determination of the extent of formation of these adducts of genotoxic agents with protein provides a practical method of monitoring human exposure and of determining the possible risk associat...

journal_title：Archives of toxicology

authors： Bailey E,Farmer PB,Shuker DE

更新日期：1987-01-01 00:00:00

abstract：:Polyclonal antibodies raised toward a debrisoquine 4-hydroxylating cytochrome P-450 species purified from rat liver (P-450UT-A) were used to determine which monooxygenase reactions are linked to debrisoquine hydroxylation in human liver. Anti P-450UT-A did not inhibit the oxidation of dimethylnitrosamine, morphine, di...

journal_title：Archives of toxicology

authors： Wolff T,Distlerath LM,Worthington MT,Guengerich FP

更新日期：1987-01-01 00:00:00

abstract：:Using the rat liver foci bioassay a dose-response relationship was evaluated for the promoting activity of the ubiquitous and persistent environmental pollutants polychlorinated biphenyls (PCBs) and chloroform. Initiation of liver foci was performed by oral administration of a single dose of 8 mg/kg body wt of diethyl...

journal_title：Archives of toxicology

authors： Deml E,Oesterle D

更新日期：1987-01-01 00:00:00

abstract：:Spin trapping in vivo was first achieved in the author's laboratory and is shown to be a feasible method for demonstrating that highly reactive free radical intermediates are generated in the tissues of intact animals as a result of the exposure to certain toxic compounds and to ionizing radiation. The method is based...

journal_title：Archives of toxicology

authors： McCay PB

更新日期：1987-01-01 00:00:00

abstract：:Daily administration of 2g/kg/day di(2-ethylhexyl)phthalate (DEHP) to immature rats was found to cause testicular atrophy and reduce zinc concentration. Specific activities of testicular enzymes associated with postmeiotic spermatogenic cells, such as lactate dehydrogenase isozyme-X, hyaluronidase and sorbitol dehydro...

journal_title：Archives of toxicology

authors： Oishi S

更新日期：1986-12-01 00:00:00

abstract：:The toxicity of 60 micrograms/kg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) given IP in corn oil/5% acetone was examined in male Sprague-Dawley rats adapted to 25 degrees C or 4 degrees C ambient temperature. Cold exposure significantly reduced mean time to death and tended to increase mortality. Body weight at the ti...

journal_title：Archives of toxicology

authors： Rozman K,Greim H

更新日期：1986-12-01 00:00:00